Krystexxa

Krystexxa (pegloticase) is an enzyme made to specifically target uric acid in the treatment of chronic gout. Krystexxa is used for patients that have failed to have success with other treatments.

Uric acid is created when the body breaks down purines, a chemical compound that cells use to make DNA and RNA. Purines can also be ingested as they are found in high purine foods such as some seafood, meats, alcohol, and sweet drinks.

In normal amounts, uric acid is passed through the urinary tract to exit the body. When the kidneys are unable to remove enough excess uric acid from the bloodstream, it results in hyperuricemia. The uric acid clumps together forming crystals. These crystals prefer to accumulate in joints, especially in the hands and feet, a condition known as gout. 

Krystexxa is given to treat severe, treatment-refractory, chronic gout because the enzyme converts uric acid into allantoin, a water-soluble substance the body can easily excrete. This process decreases uric acid levels in the blood, and over time Krystexxa dissolves uric acid crystal buildup, relieving gout symptoms and flares.

What is Krystexxa?

What Does Krystexxa Treat?

  • Severe chronic gout

  • Gout flare

  • Infusion reaction

  • Allergic reaction

  • Nausea

  • Vomiting

  • Bruising

  • Chest pain

  • Sore throat

  • Constipation

  • Click here for additional side effects

Possible Side Effects

Infusion Duration

2 hours

Infusion Cycle

Every 2 weeks

What to Expect During Your Infusion:

  1. Remember to drink plenty of water so you are hydrated for your appointment.

  2. Your nurse will review your medical history, check your vitals, and discuss any questions and potential side effects of your infusion therapy.

  3. Your nurse will begin your infusion and monitor you closely during your treatment.

  4. You’ll continue to be monitored for 30 minutes post your infusion to ensure there are no reactions to the therapy.

IMPORTANT: Remember to let us know of any changes in your insurance prior to your visit to ensure that we are still an in-network provider for your infusion therapy.​

Why Patients Choose Flourish for Infusion Treatments

At Flourish, our mission is providing patients with expert medical care and a relaxing spa-like infusion experience. Data suggests that care at ambulatory infusion centers costs over 50% less than the same services offered at hospitals. We also increase affordability with co-pay assistance and additional financial aid programs to our patients. Our clinical model ensures a 3:1 patient to nurse ratio. Popular entertainment streaming options, high speed WiFi access, relaxing recliners, and delicious food and beverage selections pamper patients and provide them with an experience they can enjoy for hours.