Leqvio

Leqvio is used to lower bad cholesterol (LDL-C) in patients suffering from atherosclerotic cardiovascular disease (ASCVD).

The liver controls lower density lipoprotein cholesterol (LDL-C) levels in the circulation by controlling the production of LDL-C and the clearance of it via the LDL receptors.

The clearance of LDL-C from the bloodstream is disrupted by PCSK9, which reduces the number of LDL receptors available to remove LDL-C from circulation.

Leqvio is a small interfering RNA for LDL-C reduction that selectively targets the liver. After Leqvio administration, it is selectively taken up by the liver cells.

Leqvio is rapidly cleared from the bloodstream and reaches undetectable levels within 48 after administration. Leqvio is slowly released inside the cell where it loads onto the RNA induced silencing complex (RISC).

Once loaded the complex that consists of Leqvio and the body’s naturally occurring RISC successively cuts multiple copies of PCSK9 mRNA continuously, preventing its production to increase the number of LDL receptors on the surface of the liver cells, which results in greater liver acceptance of circulating LDL-C, as a result Leqvio reduces LDL-C in the bloodstream.

What is Leqvio?

  • Heterozygous familial hypercholesterolemia (HeFH)

  • Clinical atherosclerotic cardiovascular disease (ASCVD), who require additional lowering of LDL-C

What Does Leqvio Treat?

  • Injection site reaction

  • Joint pain

  • Urinary tract infection

  • Diarrhea

  • Bronchitis

  • Pain in extremities

  • Dyspnea

  • Click here for additional side effects

Possible Side Effects

Injection Appointment Duration

5-10 minutes

Infusion Cycle

The first two injections 3 months apart then every 6 months thereafter

What to Expect During Your Infusion:

  1. Remember to drink plenty of water so you are hydrated for your appointment.

  2. Your nurse will review your medical history, check your vitals, and discuss any questions and potential side effects of your infusion therapy.

  3. Your nurse will begin your infusion and monitor you closely during your treatment.

  4. You’ll continue to be monitored for 30 minutes post your infusion to ensure there are no reactions to the therapy.

IMPORTANT: Remember to let us know of any changes in your insurance prior to your visit to ensure that we are still an in-network provider for your infusion therapy.​

Why Patients Choose Flourish for Infusion Treatments

At Flourish, our mission is providing patients with expert medical care and a relaxing spa-like infusion experience. Data suggests that care at ambulatory infusion centers costs over 50% less than the same services offered at hospitals. We also increase affordability with co-pay assistance and additional financial aid programs to our patients. Our clinical model ensures a 3:1 patient to nurse ratio. Popular entertainment streaming options, high speed WiFi access, relaxing recliners, and delicious food and beverage selections pamper patients and provide them with an experience they can enjoy for hours.